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Frank Lyko Selected Research

CP 4200

9/2013The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.
5/2010Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy.

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Frank Lyko Research Topics

Disease

29Neoplasms (Cancer)
01/2021 - 01/2003
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2018 - 08/2005
4Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2018 - 08/2005
4Myeloid Leukemia (Leukemia, Myelocytic)
10/2014 - 04/2008
4Leukemia
09/2013 - 01/2006
3Colonic Neoplasms (Colon Cancer)
01/2020 - 03/2011
3Carcinogenesis
09/2017 - 02/2007
3B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
05/2006 - 01/2003
2Colitis
01/2020 - 05/2015
2Inflammation (Inflammations)
01/2020 - 01/2018
2Genomic Instability
01/2018 - 02/2007
1Azoospermia
01/2021
1Malnutrition (Nutritional Deficiencies)
01/2020
1Triploidy
10/2015
1Neoplasm Metastasis (Metastasis)
02/2013
1Adenocarcinoma of Lung
02/2013
1Teratoma (Teratoid Tumor)
11/2012
1Lung Neoplasms (Lung Cancer)
01/2012
1Breast Neoplasms (Breast Cancer)
11/2010
1Adenocarcinoma
07/2010
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2010
1Colorectal Neoplasms (Colorectal Cancer)
04/2005

Drug/Important Bio-Agent (IBA)

22DNA (Deoxyribonucleic Acid)IBA
01/2021 - 06/2003
17MethyltransferasesIBA
10/2014 - 06/2003
8Pharmaceutical PreparationsIBA
10/2014 - 03/2006
8Azacitidine (5 Azacytidine)FDA Link
09/2013 - 08/2005
7DecitabineFDA Link
10/2014 - 08/2005
6EnzymesIBA
09/2017 - 03/2006
5CytosineIBA
10/2009 - 01/2003
4Proteins (Proteins, Gene)FDA Link
01/2021 - 06/2003
3NucleosidesIBA
09/2013 - 04/2008
3MicroRNAs (MicroRNA)IBA
11/2010 - 02/2007
2ChromatinIBA
01/2020 - 05/2015
2Histones (Histone)IBA
10/2019 - 11/2010
2RNA (Ribonucleic Acid)IBA
01/2018 - 10/2009
2Biomarkers (Surrogate Marker)IBA
10/2014 - 09/2013
2CP 4200IBA
09/2013 - 05/2010
2RG108IBA
03/2006 - 03/2006
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2020
1Staphylococcal Protein A (Protein A)IBA
01/2020
1Dextrans (Dextran)FDA Link
01/2020
1CytokinesIBA
01/2018
1SD-208IBA
01/2018
1ElementsIBA
01/2018
1Transforming Growth Factors (Transforming Growth Factor)IBA
01/2018
1tRNA MethyltransferasesIBA
01/2018
1DNA Transposable Elements (Element, IS)IBA
01/2018
1Oxidoreductases (Dehydrogenase)IBA
09/2017
1alpha-hydroxyglutarateIBA
09/2017
1isocitric acid (isocitrate)IBA
09/2017
1A-Form DNA (A-DNA)IBA
10/2014
1Nucleoside Transport Proteins (Nucleoside Transporter)IBA
09/2013
1Equilibrative Nucleoside Transporter 1IBA
09/2013
1matrigelIBA
11/2012
1hydrogen sulfite (bisulfite)IBA
01/2012
1Estrogen ReceptorsIBA
11/2010
1Estrogen Receptor alphaIBA
11/2010
1Histone Deacetylases (Histone Deacetylase)IBA
11/2010
1nanaomycin AIBA
11/2010
1Histone MethyltransferasesIBA
11/2010
1Therapeutic UsesIBA
07/2010
1elaidic acidIBA
05/2010
1Protein MethyltransferasesIBA
05/2010
15-azacytosineIBA
07/2008
1Nuclear Proteins (Protein, Nuclear)IBA
02/2007
1A-factor (Streptomyces)IBA
05/2006
1Recombinant DNA (Recombinant DNA Research)IBA
03/2006
1pyrimidin-2-one beta-ribofuranosideIBA
03/2006
1Oligonucleotide ProbesIBA
04/2005
1Biological ProductsIBA
06/2004

Therapy/Procedure

18Therapeutics
10/2019 - 06/2003